Pharmacological Enhancement of Autophagy: Drugs That Mimic Fasting at the Cellular Level
Fasting works largely by switching on cellular recycling. Spermidine, mTOR inhibitors, and next-generation compounds aim to trigger autophagy without hunger…
Russian Research on Cellular Renewal and Organ Regeneration: Programs and Directions
From Bogdanov's blood institute to modern RAS programs in cell biology and regenerative medicine. An overview of Russia's contributions to…
The Blueprint Protocol: Bryan Johnson’s Personal Experiment in Biomarker-Driven Prevention
Over 100 daily pills, relentless biomarker tracking, and a reported multi-million-dollar annual budget. What Blueprint actually measures, which parts rest…
Physical Activity and VO2 Max: The Most Proven Strategy for Extending Healthy Life
No pill matches what movement does: higher aerobic fitness predicts lower mortality better than cholesterol or blood pressure. The physiology…
Hormesis and Biological Aging: Mechanistic Foundations of Mild Stress-Induced Longevity
1. Introduction: The Evolutionary Rationale of Anticipatory Defense The concept of hormesis, derived from the Greek word hormos (meaning «excitation»…
Young Blood and Growth Factors: Parabiosis, Exosomes, and the Future of Plasmatherapy
1. Introduction: The Ancient Concept Meets Modern Geroscience The notion that young blood possesses rejuvenating properties is among the oldest…
Mitochondrial Therapeutics: Restoring the Powerhouses of the Cell in Aging and Disease
1. Introduction: The Mitochondrial Paradigm in Geroscience and Medicine Mitochondria are universally recognized as the primary bioenergetic hubs of eukaryotic…
Caloric Restriction Versus Intermittent Fasting: Mechanistic Foundations, Clinical Evidence, and Translational Perspectives
1. Introduction: Dietary Interventions as Modulators of Biological Agin The relationship between nutrient availability and lifespan has been recognized for…
Hyperbaric Oxygen Therapy and Telomere Dynamics: A Critical Analysis of the Landmark Israeli Clinical Trial
1. Introduction: The Quest for Reversing Biological Aging The paradigm of aging research has shifted dramatically over the past decade,…
Rapamycin and mTOR Inhibitors: From Transplantology to Anti-Aging Therapy
1. Introduction: The Evolutionary Conservation of Nutrient Sensing The pharmacological modulation of aging was long considered a theoretical impossibility, confined…