The TRIIM Trial: Growth Hormone, Metformin, DHEA, and the First Attempt at Human Thymus Rejuvenation
Nine men, one year, growth hormone plus metformin - and epigenetic clocks that ran backward. Inside the landmark TRIIM study,…
The Klotho Protein and Longevity: From Mineral Metabolism to Cognitive Rejuvenation
Mice lacking Klotho age in weeks; mice with extra Klotho live 30% longer and think better. The biology of the…
GPX4, Ferroptosis, and a New Generation of Senolytics: Killing Senescent Cells via Metabolic Vulnerabilities
Senescent cells survive by disabling their own death programs. Ferroptosis - iron-driven cell death held back by GPX4 - exposes…
Pharmacological Enhancement of Autophagy: Drugs That Mimic Fasting at the Cellular Level
Fasting works largely by switching on cellular recycling. Spermidine, mTOR inhibitors, and next-generation compounds aim to trigger autophagy without hunger…
Thymus Regeneration and Immune Rejuvenation: Restoring the Organ of T-Cell Youth
The thymus shrinks from youth to old age, and immunity ages with it. How FOXN1, growth hormone, and bioengineered thymic…
Khavinson Peptide Bioregulators: Thymalin, Epithalamin, and Tissue-Specific Rejuvenation
Tissue-specific short peptides as regulators of aging - the Khavinson school's half-century program. What thymalin and epithalamin are, what trials…
Alexander Bogomolets and the Antireticular Cytotoxic Serum: The Soviet Quest Against Aging
In the 1930s the USSR backed a serum against aging at the highest state level. The science of Bogomolets's antireticular…
Alexander Bogdanov and Rejuvenation by Blood Transfusion: The 1920s Experiments That Anticipated Young-Blood Science
A century before parabiosis made headlines, a Soviet physician founded the world's first blood institute to test transfusion as rejuvenation.…
Population-Scale Genomic Profiling: Toward Personalized Prediction of Aging Trajectories
Half a million genomes plus decades of health records: UK Biobank, All of Us, and national genome projects are learning…
METiS TechBio: AI-Designed Nanomaterials for Targeted Delivery of Future Geroprotectors
Even perfect longevity drugs fail without delivery. How China's METiS Pharmaceuticals uses AI to design nanomaterials that carry therapeutics to…