GPX4, Ferroptosis, and a New Generation of Senolytics: Killing Senescent Cells via Metabolic Vulnerabilities
Senescent cells survive by disabling their own death programs. Ferroptosis - iron-driven cell death held back by GPX4 - exposes…
Procyanidin C1 (PCC1) as a Senolytic: A Natural Compound Targeting Senescent Cells
A grape-seed compound reported to clear senescent cells and extend mouse lifespan - then flagged with an editorial warning. The…
Senolytics: A Pharmacological Strategy for the Elimination of Senescent Cells as a Promising Direction in Geroprotection
1. Introduction. Cellular Senescence as a Fundamental Mechanism of Age-Related Pathology Aging is a multifactorial biological process driven by the…