Hormesis and Biological Aging: Mechanistic Foundations of Mild Stress-Induced Longevity
1. Introduction: The Evolutionary Rationale of Anticipatory Defense The concept of hormesis, derived from the Greek word hormos (meaning «excitation»…
Young Blood and Growth Factors: Parabiosis, Exosomes, and the Future of Plasmatherapy
1. Introduction: The Ancient Concept Meets Modern Geroscience The notion that young blood possesses rejuvenating properties is among the oldest…
Mitochondrial Therapeutics: Restoring the Powerhouses of the Cell in Aging and Disease
1. Introduction: The Mitochondrial Paradigm in Geroscience and Medicine Mitochondria are universally recognized as the primary bioenergetic hubs of eukaryotic…
Caloric Restriction Versus Intermittent Fasting: Mechanistic Foundations, Clinical Evidence, and Translational Perspectives
1. Introduction: Dietary Interventions as Modulators of Biological Agin The relationship between nutrient availability and lifespan has been recognized for…
Hyperbaric Oxygen Therapy and Telomere Dynamics: A Critical Analysis of the Landmark Israeli Clinical Trial
1. Introduction: The Quest for Reversing Biological Aging The paradigm of aging research has shifted dramatically over the past decade,…
Rapamycin and mTOR Inhibitors: From Transplantology to Anti-Aging Therapy
1. Introduction: The Evolutionary Conservation of Nutrient Sensing The pharmacological modulation of aging was long considered a theoretical impossibility, confined…
Metformin and the TAME Trial: Repurposing a Diabetic Drug for Aging and Longevity
1. Introduction: The Paradigm Shift in Geroscienc For decades, modern medicine has operated on a reductionist model, treating individual age-related…
NAD⁺ and Its Precursors (NMN, NR): Real-World Evidence from Human Clinical Trials
1. Introduction: NAD⁺ as a Central Hub of Cellular Metabolism Nicotinamide adenine dinucleotide (NAD⁺) is one of the most abundant…
Yamanaka Epigenetic Reprogramming: Resetting the Biological Clock
1. Introduction. The Epigenetic Dimension of Aging Aging has traditionally been conceptualized through the lens of accumulated genetic damage, telomere…
Senolytics: A Pharmacological Strategy for the Elimination of Senescent Cells as a Promising Direction in Geroprotection
1. Introduction. Cellular Senescence as a Fundamental Mechanism of Age-Related Pathology Aging is a multifactorial biological process driven by the…