The TRIIM Trial: Growth Hormone, Metformin, DHEA, and the First Attempt at Human Thymus Rejuvenation
Nine men, one year, growth hormone plus metformin - and epigenetic clocks that ran backward. Inside the landmark TRIIM study,…
The Klotho Protein and Longevity: From Mineral Metabolism to Cognitive Rejuvenation
Mice lacking Klotho age in weeks; mice with extra Klotho live 30% longer and think better. The biology of the…
GPX4, Ferroptosis, and a New Generation of Senolytics: Killing Senescent Cells via Metabolic Vulnerabilities
Senescent cells survive by disabling their own death programs. Ferroptosis - iron-driven cell death held back by GPX4 - exposes…
Pharmacological Enhancement of Autophagy: Drugs That Mimic Fasting at the Cellular Level
Fasting works largely by switching on cellular recycling. Spermidine, mTOR inhibitors, and next-generation compounds aim to trigger autophagy without hunger…
Thymus Regeneration and Immune Rejuvenation: Restoring the Organ of T-Cell Youth
The thymus shrinks from youth to old age, and immunity ages with it. How FOXN1, growth hormone, and bioengineered thymic…
Khavinson Peptide Bioregulators: Thymalin, Epithalamin, and Tissue-Specific Rejuvenation
Tissue-specific short peptides as regulators of aging - the Khavinson school's half-century program. What thymalin and epithalamin are, what trials…
Alexander Bogomolets and the Antireticular Cytotoxic Serum: The Soviet Quest Against Aging
In the 1930s the USSR backed a serum against aging at the highest state level. The science of Bogomolets's antireticular…
Alexander Bogdanov and Rejuvenation by Blood Transfusion: The 1920s Experiments That Anticipated Young-Blood Science
A century before parabiosis made headlines, a Soviet physician founded the world's first blood institute to test transfusion as rejuvenation.…
METiS TechBio: AI-Designed Nanomaterials for Targeted Delivery of Future Geroprotectors
Even perfect longevity drugs fail without delivery. How China's METiS Pharmaceuticals uses AI to design nanomaterials that carry therapeutics to…
Procyanidin C1 (PCC1) as a Senolytic: A Natural Compound Targeting Senescent Cells
A grape-seed compound reported to clear senescent cells and extend mouse lifespan - then flagged with an editorial warning. The…