Procyanidin C1 (PCC1) as a Senolytic: A Natural Compound Targeting Senescent Cells
A grape-seed compound reported to clear senescent cells and extend mouse lifespan - then flagged with an editorial warning. The…
Russian Research on Cellular Renewal and Organ Regeneration: Programs and Directions
From Bogdanov's blood institute to modern RAS programs in cell biology and regenerative medicine. An overview of Russia's contributions to…
The Blueprint Protocol: Bryan Johnson’s Personal Experiment in Biomarker-Driven Prevention
Over 100 daily pills, relentless biomarker tracking, and a reported multi-million-dollar annual budget. What Blueprint actually measures, which parts rest…
Calico and the AI-Driven Search for the Molecular Mechanisms of Aging
Google's longevity company has spent a decade mapping aging biology with machine learning. What Calico discovered about the genetics of…
ER-100 and Partial Reprogramming in Humans: OSK Gene Therapy for the Visual System
Life Biosciences' ER-100 delivers Yamanaka factors to the aging eye. How the first human partial-reprogramming therapy works, what the optic-nerve…
NewLimit and Epigenetic Rejuvenation: Reprogramming Aged Cells Without Losing Identity
Founded by Coinbase's Brian Armstrong, NewLimit hunts transcription factors that restore youth to old cells. The science of epigenetic reprogramming…
Altos Labs and Cellular Reprogramming: A Multibillion-Dollar Bet on Reversing Aging
Backed by Bezos and Milner, Altos Labs pursues cellular rejuvenation through reprogramming. Inside the best-funded longevity startup in history -…
Retro Biosciences and the Goal of Ten Extra Healthy Years: Autophagy, Reprogramming, and RTR242
Sam Altman's longevity bet aims for a decade of additional healthy life. How Retro Biosciences pursues autophagy enhancement and cell…
Ultraviolet Protection and Skin Aging: Sunscreen, Photoaging, and Melanoma Prevention
UV radiation is the main external driver of skin aging and skin cancer. How photodamage works, what daily sunscreen actually…
Alcohol Restriction and Longevity: Reducing a Modifiable Burden on Liver, Brain, and Lifespan
Even moderate drinking raises cancer and cardiovascular risk; heavy use destroys a decade of life. The epidemiology of ethanol harm,…