Cancer Gene Therapy: Vectors, Suicide Genes, and the Tumor-Suppressor Approach
1. Introduction: Treating Cancer at the Level of Genes Cancer is fundamentally a genetic disease: mutations in oncogenes, tumor-suppressor genes,…
Differentiation Therapy in Leukemia: Retinoids, IDH Inhibitors, and the APL Paradigm
1. Introduction: Making Cancer Cells Grow Up Instead of Killing Them Differentiation therapy takes a fundamentally different approach from cytotoxic…
Hematopoietic Stem Cell Transplantation in Cancer: Autologous and Allogeneic Approaches
1. Introduction: A Systemic Therapy with Two Curative Logics Hematopoietic stem cell transplantation (HSCT) is the most aggressive systemic treatment…
Targeted Therapy and Personalized Oncology Drugs: The Paradigm Shift in Precision Medicine
1. Introduction: The Transition from Empirical to Precision Oncology For the majority of the 20th century, the systemic treatment of…