External Beam Radiotherapy: DNA Damage, Fractionation, and Curative and Palliative Use
1. Introduction: Ionizing Radiation as a Therapeutic Tool Radiotherapy is used in roughly half of all cancer patients at some…
Curative Cancer Surgery: Principles of Oncologic Resection, Margin Status, and the Shift Toward Organ Preservation
1. Introduction: Local Control as the Determinant of Cure Oncology has been transformed over the past two decades by systemic…
Multi-Omic Early Cancer Diagnosis: Integrating Proteins, Metabolites, and Tumor DNA into a Unified Detection Framework
1. Introduction: From Single-Analyte Biomarkers to Systems-Level Diagnosis The clinical trajectory of a malignant neoplasm is determined less by its…
Oncolytic Viruses: Repurposing Pathogens as Precision Weapons Against Cancer
1. Introduction: From Accidental Observation to Rational Design The concept of using viruses to treat cancer is not a modern…
Immune Checkpoint Inhibitors: A Paradigm-Shifting Breakthrough in Immuno-Oncology
1. Introduction: The Transition to Immunomodulatory Oncology For decades, the cornerstone of systemic cancer therapy relied on cytotoxic chemotherapy and…
Liquid Biopsy: Decoding the Tumor Microenvironment and Detecting Malignancy from a Single Drop of Blood
1. Introduction: The Paradigm Shift in Oncological Diagnostic For over a century, the histopathological examination of tissue biopsies has been…
Chimeric Antigen Receptor T-Cell Therapy: Reprogramming the Immune System for Targeted Oncology
1. Introduction: The Paradigm Shift in Cancer Immunotherap For decades, the oncological paradigm relied on a triad of modalities: surgery,…