Xenotransplantation of Genetically Modified Pig Organs: A New Reserve for Extending Human Life
Gene-edited pig kidneys and hearts are now beating inside human recipients. This review examines the genetic engineering, the first clinical…
3D Bioprinting of Organs: Engineering Transplantable Tissues for Life Extension
Printing living tissue layer by layer could end the organ shortage. This review covers bioinks, vascularization, and how far 3D-bioprinted…
Stem Cell Therapy for Tissue Regeneration and Healthy Longevity: Evidence, Limits, and Prospects
From bone-marrow transplants to iPSC-derived tissues, stem cells can rebuild what aging destroys. This review covers proven uses, the unproven…
Longevity Gene Therapy and Telomerase Activation: Rewriting the Genetic Limits of Lifespan
Delivering longevity genes and reactivating telomerase could reset cellular aging at its source. This review covers telomere biology, landmark mouse…
Exosome Therapy and Extracellular Vesicles: Cell-Free Signals for Regeneration and Rejuvenation
Cells communicate through vesicles loaded with proteins and RNA. This review examines exosome therapy as a cell-free alternative to stem…
The Gut Microbiome and Aging: Microbial Regulation of Healthspan and Longevity
Trillions of gut microbes shape immunity, metabolism, and inflammation. This review examines how the aging microbiome drives frailty - and…
Therapeutic Peptides in Geroscience: Epithalon, Thymalin, BPC-157 and the Search for Systemic Rejuvenation
Short amino-acid chains act as precise cellular signals. This review separates the physiology of therapeutic peptides from the hype -…
GLP-1 Receptor Agonists and Healthy Aging: From Diabetes Therapy to Longevity Medicine
Semaglutide and related GLP-1 drugs reduce cardiovascular risk and body weight. This review examines whether incretin therapies can slow aging…
Hormesis and Biological Aging: Mechanistic Foundations of Mild Stress-Induced Longevity
1. Introduction: The Evolutionary Rationale of Anticipatory Defense The concept of hormesis, derived from the Greek word hormos (meaning «excitation»…
Young Blood and Growth Factors: Parabiosis, Exosomes, and the Future of Plasmatherapy
1. Introduction: The Ancient Concept Meets Modern Geroscience The notion that young blood possesses rejuvenating properties is among the oldest…