Post-Exposure Prophylaxis (PEP) for HIV: Timing, Regimens, and Evidence
1. Introduction: Definition and Rationale Post-exposure prophylaxis (PEP) for HIV is the short-term use of antiretroviral drugs to prevent infection…
Lenacapavir: A First-in-Class Capsid Inhibitor for Six-Monthly HIV Prevention and Treatment
1. Introduction: A New Class of Antiretroviral For four decades, the pharmacological treatment and prevention of HIV-1 has been dominated…
Long-Acting Cabotegravir for HIV Prevention: Injectable Pre-Exposure Prophylaxis
1. Introduction: Injectable Pre-Exposure Prophylaxis Cabotegravir is an integrase strand transfer inhibitor (INSTI) that was reformulated as a long-acting injectable…
The Dapivirine Vaginal Ring: Topical Pre-Exposure Prophylaxis for Women
1. Introduction: A Topical Option for Women’s HIV Prevention HIV prevention has historically relied heavily on tools that are either…
Oral Pre-Exposure Prophylaxis (TDF/FTC and TAF/FTC): Pharmacology, Landmark Trials, and Real-World Impact
1. Introduction: Preventing HIV Before Exposure Pre-exposure prophylaxis (PrEP) is the use of antiretroviral medication by HIV-negative people before potential…
Broadly Neutralizing Antibodies (bNAbs): A New Weapon Against HIV
1. Introduction: The Paradigm Shift in HIV Immunology For decades, the development of an effective HIV-1 vaccine and curative therapeutics…